Cholinergic Compounds. XIV.1: Synthesis of cis-2-methyl-5-dimethylaminomethyl-1,3-oxa thiolane methiodide |
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| Authors: | M. Pigini M. Giannella F. Gualtieri |
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| Affiliation: | Institute of Pharmaceutical and Organic Chemistry , University of Camerino , 62032, Camerino (MC), Italy |
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| Abstract: | In order to get information about the role of the oxygen atom in position 1 of dioxolane I and thus about the corresponding binding site of the muscarinic receptor, Elferink and Salemink2 have synthesized the sulfur analog II as a cis/trans mixture in a 4:1 or 8:1 ratio, depending upon the synthetic method. This compound proved to be very active as muscarinic agent and might provide useful tool in Structure-Activity Relationship (SAR) studies on muscarinic receptor, if it were available as a pure cis form3. |
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