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Synthesis of Unsymmetrical 1,4-Diketones Via the Michael-Stetter Reaction |
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| Authors: | Richard B Phillips Sue A Herbert Albert J Robichaud |
| Institution: | FMC Corporation, Agricultural Chemical Group , Princeton, NJ, 08540 |
| Abstract: | The cyanide catalyzed 1,4-Michael addition of aldehydes to α, β-unsaturated ketones has been examined with regard to substituent effects. Adjustment of the donor/acceptor relationship allows for the synthesis of multisubstituted diaryl 1,4-diketones. |
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