A Practical Synthesis of 2,4-Dichloro-3-methyl-6-nitrophenol |
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| Authors: | Ruicheng Ran Charles U. Pittman Jr. |
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| Affiliation: | University/Industry Chemical Research Center, Department of Chemistry , Mississippi State University , Mississippi State, MS 39762 |
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| Abstract: | 2,4-Dichloro-3-methyl-6-nitrophenol 2 was prepared by KOH/H2O hydrolysis of a product mixture obtained from chlorination of p-nitrotoluene in the presence of a phase transfer catalyst. A 95–99% yield of 2 based on 2,3,6-trichloro-4-nitrotoluene, 4 (major chlorination product) was achieved in >95% purity. |
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