Stereoselective Reduction of Cyclic 2, 3-Epoxyketones to Trans-2,3-Epoxyalcohols |
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| Authors: | G Rücker H Hörster W Gajewski |
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| Institution: | 1. Pharmazeutisches Institut der Rheinischen Friedrich-Wilhelms-Universit?t , Bonn;2. Institut für Pharmazeutische Biologie und Phytochemie der Westf?lischen Wilhelms-Universit?t , Münster |
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| Abstract: | No qeneral method for the preparation of trans-2,3-epoxyalcohols (2) by reduction of the corresponding epoxyketones (1) with borohydrides2) is described in the literature3). Reaction conditions for each epoxyketone have to be individually established to obtain a high yield of the trans-alcohol4)(2). |
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