A Short New Synthesis of Ethyl trans-Chrysanthemate |
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Authors: | A. V. Rama Rao M. Narayana Rao Kamini Garyali |
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Affiliation: | National Chemical Laboratory , Pune, 411 008 |
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Abstract: | The discovery of synthetic pyrethroids with increased insecticidal activity and low mammalian toxicity led to abundance of new synthetic results in the chemistry of pyrethroids1 . Many of these methods adopted on an industrial scale make use of sigmatropic rearrangement, radical addition and nucleophilic ring closer with carbanions. Herein we report a simple and stereospecific route for the synthesis of ethyl trans-chrysanthernate (1) by utilizing carbonyl stabilized sulphuranes. Although the use of Sulphurane was demonstrated at a much earlier stage for the synthesis of methyl trans-chrysanthe-mate2, the present approach makes use of simple reagents and offers some operational advantages. |
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