Reduction of Phenyl-Substituted Pyridinium Methoiodides with Sodium Borohydride. Formation of Amine-Borane Complexes in Water |
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| Authors: | Wieslaw Gessner Arnold Brossi |
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| Affiliation: | Section on Medicinal Chemistry, Laboratory of Chemistry , NIADDK National Institutes of Health , Bethesda, Maryland, 20205 |
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| Abstract: | Reduction of phenyl-substituted pyridinium methoiodides with sodium borohydride in water afforded besides the desired tetrahydropyridines substantial amounts of amine-borane complexes. Reduction in methanol afforded tetrahydropyridines in high yield, with almost no amine-boranes formed. |
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