Potassium Fluoride on Alumina: Condensation of 1,4-Diacetylpiperazine-2,5-Dione with Aldehydes. Dry Condensation Under Microwave Irradiation. Synthesis of Albonursin and Analogues |
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| Authors: | Didier Villemin Abdelkrim Ben Alloum |
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| Institution: | I.SM.Ra, UA.480 CNRS , Université de Caen , F 14050, Caen cedex, France |
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| Abstract: | 1,4-Diacetylpiperazine-2,5-dione (1) was condensated with aldehydes (2) with KF on alumina without solvent under microwaves or in at room temperature in the presence of DMF. The reaction was stereoselective and some natural products (4a-c) like albonursin(4c) were synthesized. |
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