Improved Synthesis of Tricyclo (5.2.1.04,10) Decane-2,5,8-Trione by a Pauson-Khand Intramolecular Bis-Annulation |
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| Authors: | Carmen Almansa Elena Carceller M. Lluïsa García Alba Torrents Fèlix Serratosa |
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| Affiliation: | Department de Química Orgànica , Universitat de Barcelona , Martí i Franqués, 1-11, E-08028, Barcelona, Spain |
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| Abstract: | The title compound 1 has been synthesized from diol 3a, either directly or after protection of the two hydroxy groups as benzyl ethers, by an intramolecular Pauson-Khand bis-annulation, followed by catalytic hydrogenation and oxidation in overall yields ranging from 15% (free diol) to 35% (dibenzyl ethers). |
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