A Convenient Synthesis of 3-Alkylthiophenes |
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| Authors: | Chiem Van Pham Harry B. Mark Jr. Hans Zimmer |
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| Affiliation: | Department of Chemistry , University of Cincinnati , Cincinnati, OH, 45221 |
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| Abstract: | The known procedures for the synthesis of 3-alkylthiophenes are rather lengthy or involved. By using the NiDPPP++ catalyzed cross-coupling method between 3-bromothiophene and Grignard reagents derived from alkyl halides a number of 3-alkylthiophenes have been prepared in a one-step reaction in good to excellent yields. |
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