A Facile Route to Quinazolin-4(3H)-ones Functionalised at the 2-Position |
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| Authors: | V. Bavetsias |
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| Affiliation: | CRC Centre for Cancer Therapeutics , The Institute of Cancer Research, CRC Laboratory , 15 Cotswold Road, Sutton, Surrey , SM2 5NG , UK |
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| Abstract: | Treatment of 2-methoxyacetamidobenzonitriles or 2-chloroacetamidobenzonitrile with UHP and K2CO3 provides a convenient route to 2-methoxymethyl-or 2-chloromethylquinazolin-4(3H)-ones. In addition, demethylation of 2-methoxymethylquinazolin-4(3H)-ones with 48% HBr gives 2-hydroxymethylquinazolin-4(3H)-ones. |
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