Direct Phosphorylation of N-Protected Imidazoles and Benzoimidazoles-A Route to 1H-Imidazol(benzoimidazol)-2-yl Phosphonic and Phosphinic Acids and Their Derivatives |
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| Authors: | Igor V. Komarov Aleksandr V. Strizhak Mikhail Yu.Kornilov Aleksandr N. Kostyuk Andrey A. Tolmachev |
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| Affiliation: | 1. Department of Chemistry , Kiev Taras Shevchenko University , Vladimirskaya street, 64, Kiev, 252033, Ukraine;2. Institute of Organic Chemistry of National Academy of Sciences of Ukraine , Kiev, Murmanskaya street, 5, Kiev, 252094, Ukraine |
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| Abstract: | Synthetic approaches to 1H-imidazol-2-yl and 1H-benzoimidazol-2-yl phosphinic and phosphonic acids and their derivatives are reported, based on phosphorylation of N-protected heterocylcles by PhPOCl2 or MePOCl2. Reaction of N-alkylbenzoimidazoles with POCl3 did not lead to C-phosphorylated products in a reasonable yield, [2,2′]-bis-benzoimidazolyles being formed instead. |
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