Regioselective A-Ring Chlorination of Benzodiazepine Analogues Using tert-Butyl Hypochlorite |
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| Authors: | Perry T. Kaye M. Jack Mphahlele |
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| Affiliation: | Department of Chemistry , Rhodes University , P.O Box 94, Grahamstown, 6140, South Africa |
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| Abstract: | Treatment of 2-phenyl-2,3-dihydro-1,4-benzodiazepin-5(4H)-one and a series of 1,4-benzoxazepinone analogues with tert-butyl hypochlorite affords products shown, by NMR and MS spectroscopy, to be chlorinated exclusively in the A-ring at positions 7 and/or 9. |
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| Keywords: | Arylaldehydes chalcones hydrotalcites solid base |
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