Stereoselective Borane Reduction of Acetophenone using 1,3,2-Oxazaborolidine Derived from (R)-4-(Diphenylhydroxymethyl)-1,3-Thiazolidine |
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| Authors: | Monique Calmes Francoise Escale |
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| Affiliation: | Laboratoire des Aminoacides, Peptiees et Protéines, UMR 5810 Universités Montpellier I et II , UMII, Place E. Bataillon, 34095, Montpellier cedex 5, France |
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| Abstract: | A new chiral 1, 3, 2-oxazaborolidine derived from (R)-4-(diphenylhydroxymethyl)-l, 3-thiazolidine has been synthesized and its efficiency in the asymmetric reduction of acetophenone by borane has been investigated. It gives (R)-l-phenylethanol with high enantiomeric excess |
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| Keywords: | Phosphono substituted-heterocycles Acrylonitriles Wittig-Horner synthons Michael addition |
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