Resolving Agents. I. (R)-(-)-2-Amino-1-benzyloxybutane,a New Base for the Resolution of Racemic Acids |
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| Authors: | Joel Touet Thierry Ruault Eric Brown |
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| Institution: | Laboratoire de Synthèse Organique (URA-CNRS 482) , Faculté des Sciences , avenue Olivier Messiaen, BP 535, F-72017, Le Mans, France |
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| Abstract: | Treatment of the readily available (R)-(-)enantiomer of 2-aminobutan-1-ol 1 with sodium hydride followed by benzyl chloride afforded the O-benzyl base (R)-(-)-2. The latter was successfully used for the resolution of racemic α-methylsuccinic and α-bromosuccinic acids, as well as of the racemic α-benzylhemisuccinic esters 8 and 9 resectively. |
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