A Versatile Synthesis of 3-Substituted Indoles |
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| Authors: | Alan R Katritzky Linghong Xie Darren Cundy |
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| Institution: | Center for Heterocyclic Compounds, Department of Chemistry , University of Florida , Gainesville, FL, 32611-7200, USA |
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| Abstract: | A variety of 3-substituted indoles are prepared from 1-methyl-3-(benzotriazol-1-ylalkyl)indoles (1), which are readily available either from the condensation of 3-methylindole with N-(benzotriazol-1-ylalkyl)carbamates or from the alkylation and silylation of lithiated 1-methyl-3-(benzotriazol-1-ylmethyl)indole (2). |
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