Expedient and High-Yield Synthesis of Alkylphos-Phonyl Bichlorides Under Mild,Neutral Conditions: Reaction of Bis(Trimethylsilyl)Alkyl Phosphonates with Oxalyl Chloride/Dimethylformamide |
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| Authors: | Nandkumar N Bhongle Robert H Notter Joseph G Turcotte |
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| Institution: | 1. Department of Medicinal Chemistry , University of Rhode Island , Kingston, Rhode Island , 02881;2. Department of Chemical Engineering , University of Rochester , Rochester, New York, 14642 |
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| Abstract: | Structurally variant bis(trimethylsilyl)alkyl phosphonates were converted in high yields (80–88%, distilled) to the corresponding phosphonyl dichlor-ides upon reaction with (COCl)2/DMF. |
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