One-Stage Monosubstitution in Cyclen - Two Novel Examples |
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Authors: | A A Formanovsky I V Mikhura |
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Institution: | Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry , 117871, Moscow, Russia |
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Abstract: | Two new routes for alkylsubstituton of one in four amino groups in 1,4,7,10-tetraazacyclododecane (cyclen) are described, isomeric N-tris(hydroxy)butylcyclens 4 and 6 have been obtained in very good yields. Further carboxymethylation of other three amino groups afforded 10-tris(hydroxy)butyl-1,4,7-tris(carboxymethyl)cyclens 1 and 2. |
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