A Useful Synthesis of 2-Methyl-2,3-dihydrofuro [2,3-b] Quinolines |
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| Authors: | R. S. Mali S. G. Tilve |
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| Affiliation: | Garware Research Centre, Department of Chemistry , University of Poona , Pune, 411 007 |
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| Abstract: | A convenient, general synthesis of 2-methyl-2,3-dihydrofuro [2,3-b] quinolines is described from o-nitrobenzaldehydes. The benzaldehydes (la-c) on reaction with phosphorane 2 provide (E)-ethyl-α-allylcinnamates (3a-c) in high yields. These esters 3a-c on reduction followed by acid catalysed cyclisation give 2,3-dihydrofuro [2,3-b] quinolines (5a-c). |
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