Facile Synthesis of 1,2-Dialkyl-3-Phenyl-4-Quinolinones |
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| Authors: | Gary M Coppola |
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| Institution: | Sandoz Research Institute Chemistry Research Department Sandoz , Inc. Route 10, East Hanover, New Jersey, 07936 |
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| Abstract: | The synthesis of 1,2-dialkyl-3-phenyl-4-quinolinones (1) is readily accomplished by a low-temperature reaction of an N-alkylisatoic anhydride with the therraodynamic potassium enolate of phenyl-acetone. The reaction has also been extended to encompass the synthesis of the more complex 2-(3-hydroxy-propyl)-3-(4-fluorophenyl)-1-methyl-4(1H)-quinolinone (10). |
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