Reduction and N-Alkylation of α-Methylene-indolines with Sodium Cyanoborohydride in Carboxylic Acids |
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| Authors: | Emilia R Balogh Bela Zsadon Antal Csámpai R Pál |
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| Institution: | 1. E?tv?s University Budapest, Institute of Chemistry , H-1518, Budapest, 112, P. O. Box 32, Hungary;2. Hungarian Oil and Gas Co., Development and Marketing Division , H-2443, Százhalombatta, P. O. B. 1, Hungary |
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| Abstract: | The reaction of α-methylene-indolines with NaCNBH3 in carboxylic acids at room temperature can yield either 2β,3β-dihydro-indolines or their N-alkyl derivatives as main products with high selectivity, depending mainly on the carboxylic acid and on the reaction time when using a large excess of NaCNBH3. |
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| Keywords: | Thienorphine X‐ray analysis glucuronide conjugate |
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