Synthesis of N-t-Boc-4-S-t-Butyl-L-thiophenylalanine via Palladium Catalyzed Cross-Coupling Reaction of N-t-Boc-4-Iodo-L-phenylalanine with t-Butylthiol or Sodium t-Butylthiolate |
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| Authors: | Shyamala Rajagopalan Gary Radke Michelle Evans John M Tomich |
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| Institution: | Department of Biochemistry , Kansas State University , Manhattan, KS, 66506 |
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| Abstract: | Cross-coupling reaction of N-t-Boc-4-iodo-L-phenylalanine with t-BuSH proceeded efficiently in the presence of Pd2dba3.CHCl3/DPPF as the catalyst system. However, Pd2dba3.CHCl3/DPPB was found to be more effective for coupling with t-BuSNa. |
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