A New Method of Cyclodehydration of 3,3-Dialkyl-1-Oxo-1-(2- hydroxyaryl)propan-3-ols to 2,2-Dialkyl-4-chromanones: Synthesis of Cannabinoid Synthon |
| |
| Authors: | A Banerji G P Kalena |
| |
| Institution: | Chemical Ecology Section Bio-Organic Division , Bhabha Atomic Research Centre , BOMBAY, 400 085 |
| |
| Abstract: | A new method for cyclodehydration of o-hydroxyaryl-β-ketols to 4-chromanones using HMPT is described. The method has general applicability. It is particularly useful for the cyclisation of labile intermediates as exemplified by the synthesis of cannabinoid synthon, 2-methyl-2-(4-methyl-3-pentenyl)-7-methoxy-4-chromanone. |
| |
| Keywords: | |
|
|
