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A Practical Synthesis of 6-Acetylsalicylic Acid Methyl Ester |
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| Authors: | Masatoshi Tamaru Kazuto Umezu Chika Maejima Hiroyuki Kageyama Yoshikazu Kimura |
| Affiliation: | 1. K-I Chemical Research Institute Co., Ltd , Fukude-cho, Iwata-gun, Shizuoka, 437-12, Japan;2. Research and Development Department , Ihara Chemical Industry Co., Ltd , Fujikawa-cho, Ihara-gun, Shizuoka, 421-33, Japan |
| Abstract: | A new and efficient synthesis of the title compound is reported. The method includes a regioselective ortho-lithiation step in none polar solvents at an ambient temperature and the overall yield for 5 steps is more than 70% from a commercially available 3-hydroxyacetophenone. |
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