Preparation and Synthetic Applications of Sterically Hindered Secondary Amines |
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Authors: | Hwa-Ok Kim Brian Carroll Min S. Lee |
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Affiliation: | Molecumetics , 2023 120th Ave. N.E., Suite 400, Bellevue, WA, 98005-2199 |
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Abstract: | The preparation of sterically hindered secondary amino esters from the reaction of N-protected α-amino aldehydes and 3-, or 2-oxo esters with α-amino esters by reductive amination is described. The resulting amino esters were converted to the β-lactam or acylated to form N-acyl secondary amides. |
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Keywords: | Disulfide Dialkylaminotrifluoro sulfurane Aryl trifluoro sulfurane |
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