A Short and Convenient Synthesis of 5-Alkyl Substituted 8-Hydroxyquinolines |
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| Authors: | Massoud Hojjatie Subramaniam Muralidharan Mark L Dietz Henry Freiser |
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| Institution: | Strategic Metals Recovery Research Facility Department of Chemistry , University of Arizona , Tucson , A.Z , 85721 |
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| Abstract: | 5-Chloro-8-methoxyquinoline undergoes rapid and reversible lithium-halogen exchange reaction with alkyllithiums to yield 5-alkyl substituted derivatives indirectly, whereas the reaction with phenyllithium is slower and 5-alkyl substituted compounds are formed by the direct addition of alkyl halides. |
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