An Improved Synthesis of 3-Substituted 1,2,4-Triazolo[4,3-a]pyridines and 1,2,4-Triazolo[4,3-b]pyridazines |
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| Authors: | Pascal Bourgeois Richard Cantegril Alain Chěne Jacques Gelin Jacques Mortier Joel Moyroud |
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| Affiliation: | 1. Rh[obreve]ne-Poulenc Secteur Agro, Centre de Recherches de la Dargoire , B. P. 9163, 69263, Lyon, Cédex, 09, France;2. Rh[obreve]ne-Poulenc Ag. Company , Research Triangle , Park, P. O. Box 12014, N. C., 27709, U. S. A. |
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| Abstract: | The preliminary results of a simple and versatile one-pot procedure for the preparation of 3-substituted 1,2,4-triazolo[4,3-a] pyridines and 1,2,4-triazolo[4,3-b]pyridazines are described. Intramolecular cyclization of nitrile imine ylides are carried out by treatment of 2-pyridyl- and 3-pyridazinylhydrazones with chloramine T. |
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