An Improved Alternative Norgestrel Preparation |
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| Authors: | Sergio FerriñTo Francisco López-Tapia Hećtor Salgado-Zamora |
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| Affiliation: | Syntex División Química , Km. 4.5 Carretera Federal a Cuautla Civac Jiutepec Mor |
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| Abstract: | Ethynyl cerium chloride, prepared in situ from ethynyl magnesium bromide or lithium acetylide and anhydrous cerium chloride efficiently added to 13-ethyl-3-methoxy-gona-3,5-diene-17-one 2. Aqueous HCl hydrolysis of intermediate enol ether 3 gave high yields of norgestrel 4. |
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