Asymmetric Synthesis VIII: Enantioselective Synthesis of (R) or (S)-α-Substituted Benzylamines VIA Chiral Pinanone Ketimine Template |
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| Authors: | Chen Yuanwei Mi Aiqiao Xiao Xun Jiang Yaozhong |
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| Institution: | Chengdu Institute of Organic Chemistry Academia Sinica , P. R. China |
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| Abstract: | An excellent asymmetric synthesis of both (R) and (S)-α-substituted benzylamines in optical purity 90.4–99.9% has been achieved by alkylation of a chiral ketimine, prepared from pinanone and benzylamine. Diastereoselectivity in the alkylation is not dependent on the alkyl halides. |
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