An Expedient Large-Scale Preparation of a Dibenz[b,e]oxepinone Derivative |
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| Authors: | Thomas B.K. Lee Andrew J. Tebben † Franz J. Weiberth George S.K. Wong † |
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| Affiliation: | Chemical Development Hoechst Marion Roussel, Inc. , Bridgewater, NJ, 08807 - 0800 |
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| Abstract: | A convenient, large-scale synthesis of a dibenz[b,e]oxepinone derivative is described. The dibenz[b, e]oxepinone ring system is constructed using an iron chloride catalyzed intramolecular Friedel-Crafts cyclization of an appropriate phenoxymethylbenzoic acid chloride in toluene, reagents and conditions that are economically and environmentally compatible with large-scale preparation. |
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