A Facile Access to (R)-Methyl 2-Oxocyclopentane-1-acetate via Lipase-Catalyzed Irreversible Transesterification |
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| Authors: | Shun-ichi Hashimoto Yoji Miyazaki Shiro Ikegami |
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| Affiliation: | Faculty of Pharmaceutical Sciences , Teikyo University Sagamiko , Kanagawa, 199-01, Japan |
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| Abstract: | A highly efficient kinetic resolution of (±)-methyl trans-2-hydroxycyclopentane-1-acetate via lipase PS-catalyzed irreversible transesterification provides a facile and economical entry to (R)-methyl 2-oxocyclopentane-1-acetate of 96% ee, a starting material for the convergent synthesis of (+)-isocarbacyclin. |
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