Novel Route to Functionalized Indans via Formal [3 + 2] Cycloadditions of 1-Benzylbenzotriazoles with Alkenes |
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| Authors: | Alan R. Katritzky Guifen Zhang Linghong Xie |
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| Affiliation: | Center for Heterocyclic Compounds, Department of Chemistry , University of Florida , Gainesville, FL, 32611-7200, USA |
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| Abstract: | α-Functionalized 1-benzylbenzotriazoles (3, 4 and 12), derived from the lithiation of 1-(2,3-dimethoxybenzyl)benzotriazole 2 followed by reactions with electrophiles, or from the condensation of benzyl alcohol 11 with benzotriazole, undergo formal [3 + 2] cycloadditions with styrenes upon treatment with ZnBr2 to give functionalized indans (9, 10, 13 and 14). |
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