Electrophilic Fluorination of a Highly Functionalized Pyrrole |
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| Authors: | Keith D. Barnes Yulin Hu David A. Hunt |
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| Affiliation: | American Cyanamid Co., Agricultural Research Division , P.O. Box 400, Princeton, New Jersey, 08543-0400 |
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| Abstract: | Bromine-lithium exchange of 3-bromo-1 -(trilsopropylsilyl) pyrrole 6 followed by treatment with N-fluorobenzenesulfonimide gave the fluoropyrrole 8. Application of this methodology to the highly functionalized pyrrole 1 afforded the fluoropyrrole 4, which was found to be inaccessible by other approaches. |
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