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Alkylation of 3-Acetylthiophene Under Phase-Transfer Conditions |
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| Authors: | Yu Goldberg E Abele M Shymanska |
| Institution: | Institute of Organic Synthesis, Latvian Academy of Sciences , Riga, 226006, Latvia, USSR |
| Abstract: | Reactions of 3-acetylthiophene with C1-C4-alkyl iodides in a two-phase benzene/solid KOH system in the presence of l8-crown-6 afford di-C-alkylated derivatives-(3-thienyl)COCHR2 in satisfactory yields (～50%) with high regioselectivity (70–100%). |
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