Nitrilotriacetamide: Synthesis in Concentrated Sulfuric Acid and Stability in Water |
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| Authors: | Douglas A. Smiths Steven Sucheck Susan Cramer David Baker |
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| Affiliation: | 1. Department of Chemistry , The University of Toledo , Toledo, OH, 43606-3390;2. Concurrent Technologies Corporation , 1450 Scalp Avenue, Johnstown, PA, 15904;3. Concurrent Technologies Corporation , 1450 Scalp Avenue, Johnstown, PA, 15904 |
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| Abstract: | Acid hydrolysis of N(CH2CN)3 leads either nitrilotriacetamide, 1, and/or 3,5-dioxopiperazineacetamide, 4, in quantitative yield. 1 slowly and cleanly converts to 3,5-dioxopiperazineacetic acid, 5, in water, although ammonium salts prevent this reaction. |
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