Practical Syntheses of Functionalized 1-Oxo-L,2,3,4-Tetrahydro-β-carboline-3-carboxylic Acid Esters |
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| Authors: | Laurent Jeannin Janos Sapi Elka Vassileva Pierre Renard Jean-Yves Laronze |
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| Institution: | 1. Laboratoire de Chimie Thérapeutique, associé au CNRS: “Isolement, Structure, Transformations et Synthèse de Substances Naturelles” , Faculté dc Pharmacie Université de Reims Champagne-Ardenne , F-51096, Reims, France;2. ADIR et Cie , 1, rue Carle Hébert, F-92415, Courbevoie, France |
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| Abstract: | Three methods have been proposed for the preparation of functionalized 1-oxo-1,2,3,4-tetrahydro-β-carboline-3 carboxylates (3) from which the “acylazide formation-Curtius rearrangement-acid catalyzed ring closure” sequence starling from hemi-ester hemi-acids (8) seemed to be quite general. |
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