Beckmann Fission of Some Fused Cyclobutanones: A New Entry into Indole-2-Acetonitriles and Benzo[b]thiophene-2-acetonitrile |
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Authors: | Masazumi Ikeda Toshiko Uno Ko-Ichi Homma Kazunori Ohno Yasumitsu Tamura |
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Institution: | Faculty of Pharmaceutical Sciences , Osaka University , 133-1, Yamada-kami, Suita, Osaka, Japan |
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Abstract: | Fused cyclobutanone derivatives have been utilized as intermediates in a variety of synthetic schemes.1) We are investigating the synthesis and ring opening reactions of cyclobutanones fused to indoles, benzob]furans, and benzob]-thiophenes, in part with the hope of discovering a novel method for introduction of two carbon atoms to such heteroaromatic systems. In this communication the synthesis and Beckmann fission2) of the cyclobutanone derivatives fused to 1-benzoyl-indoles and benzob]thiophene are described. This provides a new entry into indole-2-acetonitriles3) and benzob]thiophene-2-acetonitrile.4) |
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