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Selective Benzylic Bromination of 2-Methylnaphthalene |
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| Authors: | Liladhar Waykole Mahavir Prashad Stephen Palermo Oljan Repic Thomas J Blacklock |
| Institution: | 1. Chemical Research &2. Development Sandoz Pharmaceuticals Corporation , 59 Route 10, East Hanover, NJ, 07936, U.S.A. |
| Abstract: | A practical synthesis of 2-(bromomethyl)naphthalene (1), by selective benzylic bromination of 2-methylnaphthalene (2), with bromine in heptane in the presence of lanthanum acetate hydrate is described. |
| Keywords: | 2‐[4‐Aryloxybut‐2‐ynylthio]benzothiopyran‐4‐ones Claisen rearrangement Heterocycles Phase‐transfer catalysis Regioselective synthesis [2 3] Sigmatropic rearrangement |