Synthesis of Air and Light Sensitive Cis-phenolic Cyclopropane Derivatives |
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| Authors: | Jalees Afzal Robert A Magarian May Griffin J Thomas Pento |
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| Institution: | Department of Medicinal Chemistry and Pharmacodynamics , College of Pharmacy, University of Oklahoma Health Sciences Center , 1110 N. Stonewall, Oklahoma City, OK, 73190, USA |
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| Abstract: | The synthesis of several cis-phenolic cyclopropanes, 6, 7, 8, and 13 is described. These cyclopropanes are new potential antiestrogens. A hydrogenolysis study of precursors, 5b, 5c, 5d, 10 11, and 12 and a novel method for the prevention of gem-dichlorocyclopropane ring-opening during hydrogenolysis are discussed. |
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| Keywords: | Amide Heterocycle Pyrimidine Thiazole Thiazoldine |
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