A Novel Thermal Knoevenacel Condensation via A Thermal Michael Reaction |
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Authors: | Jalees Afzal M Vairamani B C Hazra K C Das |
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Institution: | National Chemical Laboratory , Poona, 411008, India |
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Abstract: | In connection with the total synthesis of natural products by retro-mass spectral approach,1–3 the thermal reaction between 6,7-dimethoxy-3-isochromanone 1 and benzalmalononitrile 3 was studied. The Knoevenagel condensation product4 was obtained over and above the expected Diels-Alder adduct. The scope, limitation and mechanism of the aforesaid unusual thermal Knoevenagel condensation through a thermal Michael reaction is described. |
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