DI-(2,2,2-Trichloroethyl)-Carbonate: Byproduct in Reactions with 2,2,2-Trichloroethyl Chloroformate |
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| Authors: | Xiao-Shu He Arnold Brossi |
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| Institution: | Laboratory of Structural Biology , Natural Products Section, National Institute of Diabetes, and Digestive, and Kidney Diseases, National Institutes of Health , Bethesda, Maryland, 20892, USA |
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| Abstract: | 2,2,2-Trichloroethyl chloroformate (1) in higher boiling solvents, particularly in the presence of potassium carbonate and potassium bicarbonate, affords undesired di-(2,2,2-trichloroethyl)-carbonate (2) as a byproduct. When chemically pure chloroformate was used, addition of carbonates was found to be unnecessary in N-demethylation reactions. |
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