Novel Synthesis of (+/−)-cis-4-Amino-2-cyclopentene-1-methanol,a Key Intermediate in the Preparation of Carbocyclic 2′,3′-Didehydro-2′,3′-dideoxy Nucleosides |
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| Authors: | Mark H. Norman Merrick R. Almond Barbara E. Reitter S. George Rahim |
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| Affiliation: | 1. Division of Organic Chemistry , Burroughs Wellcome Co. , Research Triangle Park, NC , 27709;2. Medicinal Chemistry Department , Wellcome Research Laboratories Beckenham , Kent , England , BR3 3BS |
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| Abstract: | Abstract Novel synthetic routes directed toward the preparation of (+/?)-cis -4-amino-2-cyclopentene-1-methanol are described. The routes investigated involve azide openings of chiral and non-chiral cyclopentyl epoxides. |
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