Thermal Removal of Boc-Protecting Groups During Preparation of Open-Chain Polyamines |
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| Authors: | Krzysztof E. Krakowiak Jerald S. Bradshaw |
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| Affiliation: | 1. IBC Advanced Technologies , Inc., PO Box 98, American Fork, UT, 84003;2. Department of Chemistry and Biochemistry , Brigham Young University , Provo, UT, 84602 |
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| Abstract: | Per-N-tosylated 3,8-diaza-1,10-decanediamine (9), 4,9-diaza-1,12-dodecanediamine (spermine) (10) and 3,6,9,14,17,20-hexaaza-1,22-docosanediamine (11) were prepared by treating mono-BOC-protected, per-N-tosylated 1,2-ethanediamine (5), 1,3-propanediamine (6) and triethylenetetraamine (7), respectively, with 1,4-dibromobutane and removing the BOC-protecting groups at 100–120 °C. |
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