Synthesis of Ethenylbenzothiazole Derivatives |
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Authors: | Setsuya Ohba Takatoshi Kosaka Toshio Wakabayashi |
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Affiliation: | Medicinal Chemistry Laboratory , Tsukuba Research Institute Sandoz Pharmaceuticals, Ltd. , 8 Ohkubo, Tsukuba, 300-33, Japan |
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Abstract: | Ethenylbenzothiazoles were synthesized by the Horner-Emmons reaction of benzothiazolylmethylphosphonate with aldehydes under phase transfer catalytic conditions in 60–71% yields. Not only aromatic but also aliphatic aldehydes gave the desired products under these mild conditions in 66–71% yields. |
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