Simple,Safe, Large Scale Synthesis of 5-Arylmethyl-2,2-dimethyl-1,3-dioxane-4,6-diones and 3-Arylpropanoic Acids |
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| Authors: | György Tóth Katalin E Kövér |
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| Institution: | Chemical Research Department , Biogal Pharmaceutical Works Ltd. , H-4042, Debrecen, Pallagi út 13., Hungary |
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| Abstract: | Reaction of aryl aldehydes with Meldrum's acid 2 in the presence of formic acid and triethylamine gives 5-arylmethyl Meldrum's acid derivatives 4 at room temperature, whereas at 80–100°C 3-arylpropanoic acids 5 are formed. |
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