Reductive Cleavage of tert-Butyldimethylsilyl Ether via Intramolecular Transfer of Hydride |
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| Authors: | Parthasarathy Saravanan Suparna Gupta Arpita DattaGupta Sonia Gupta Vinod K Singh |
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| Institution: | Department of Chemistry , Indian Institute of Technology , Kanpur , India , 208 016 |
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| Abstract: | The cleavage of α-hydroxy tert-butyldimethylsilyl ether to diol takes place efficiently with LAH. It has been proposed that the reaction proceeds via intramolecular hydride transfer from the alkoxy aluminium hydride. In order to substantiate this, reduction of TBDMS ether with LAH in a variety of substrates was studied. |
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