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Synthesis of Aminobisphosphonate |
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| Authors: | Darko Kantoci J Kane Denike William J Wechter |
| Institution: | Loma Linda University, Laboratory of Chemical Endocrinology , Loma Linda, CA, 92350 |
| Abstract: | A new facile synthesis of aminobisphosphonate was reported. Dibenzylamine bisphosphonate (1) is prepared from dibenzylamine, triethyl orthoformate and diethyl phosphite. Deprotection by hydrogen transfer reaction and acid hydrolysis afforded aminobisphosphonate (2). |
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