Highly Stereoselective Synthesis of E-α,β-Uksaturated Nitriles from Diphenyl Cyanomethyl Phcsphine Oxide. |
| |
| Authors: | Guita Etemad-moghadam Jacqueline Seyden-penne |
| |
| Institution: | Laboratoire des Réactions Sélectives sur Supports , ERA 316 du CNRS-Université Paris-Sud , B[acaron]t, 410 91405, Orsay, France |
| |
| Abstract: | The Wittig-Horner reaction from diethyl cyanomethyl phosphonate 1a and aldehydes is seldom highly stereoselective1. The use of diiscpropyl cyanomethyl phosphonate 1b has been recently proposed to improve the stereoselectivity of the reaction towards the E-α, β- unsatured nitriles 2E2. |
| |
| Keywords: | |
|
|
