An Improved and Practical Sharpless Oxidation of Primary Alcohols to the Carboxylic Acids |
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| Authors: | Mahavir Prashad Yansong Lu Hong-Yong Kim Bin Hu Oljan Repic Thomas J. Blacklock |
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| Affiliation: | 1. Process Research &2. Development, Chemical &3. Analytical Development Novartis Institute for Biomedical Research , 59 Route 10, East Hanover, New Jersey, 07936, USA |
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| Abstract: | An improved and practical procedure for the oxidation of primary alcohols to the carboxylic acids under Sharpless's conditions (NaIO4/RuCl3.H2O/water/acetonitrile) using ethyl acetate as the solvent, in place of toxic and ecologically undesirable carbon tetrachloride, is described. |
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