A Novel and Expeditious Route to A-81988: An Angiotensin II Receptor Antagonist |
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| Authors: | Francis A J Kerdesky Thomas J Sowin |
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| Institution: | Process Research, Department 45L, Pharmaceutical Products Division , Abbott Laboratories , North Chicago, Illinois, 6004 |
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| Abstract: | A novel and efficient synthesis of A-81988, an angiotensin II receptor antagonist, is described. The key step utilizes a palladium-catalyzed biaryl coupling between a phenylboronic acid derivative and N-trityl-5-(2-bromophenyl)tetrazole. |
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