Formation of Naphthoquinone Oxo-Pyridinium Inner Salts |
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| Authors: | HeXi Chang C C Cheng |
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| Institution: | Drug Development Laboratory, Department of Pharmacology , Toxicology and Therapeutics, University of Kansas Medical Center , Kansas City, KS, 66160-7419 |
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| Abstract: | When 2-chloro-3-(substitued phenoxy)naphthazarine (1) was treated with pyridine or substituted pyridine at elevated temperature, an unexpected reaction took place. The product was identified as 5,8-Dihydroxy-1,4-dioxo-3-(substituted pyridinium)-2-naphthoxide (3, 4). A reaction mechanism for the formation of this product was postulated. |
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| Keywords: | Nitric acid Oxidation Thiols Disulfides |
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